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Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50587578
Substrate
n/a
Meas. Tech.
ChEMBL_2261503 (CHEMBL5216514)
IC50
144±n/a nM
Citation
 He, G; Wan, S; Wu, Y; Chu, Z; Shen, H; Zhang, S; Chen, L; Bao, Z; Gu, S; Huang, J; Huang, L; Gong, G; Zou, Y; Zhu, Q; Xu, Y Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis. J Med Chem 65:14348-14365 (2022) [PubMed] 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_HUMAN | IDO-2 | IDO2 | INDOL1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
47079.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109909
Residue:
420
Sequence:
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  
Inhibitor
Name:
BDBM50587578
Synonyms:
CHEMBL5091825
Type:
Small organic molecule
Emp. Form.:
C16H18BrFN8O4
Mol. Mass.:
485.268
SMILES:
OCCOCc1cn(CCNc2nonc2\C(Nc2ccc(F)c(Br)c2)=N\O)nn1
Structure:
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