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Target
Cytochrome b-245 heavy chain
Ligand
BDBM318936
Substrate
n/a
Meas. Tech.
ChEMBL_2261581 (CHEMBL5216592)
IC50
1250±n/a nM
Citation
 Shahari, MSB; Dolzhenko, AV A closer look at N Eur J Med Chem 241:0 (2022) [PubMed] 
Target
Name:
Cytochrome b-245 heavy chain
Synonyms:
CGD91-phox | CY24B_HUMAN | CYBB | Cytochrome b(558) subunit beta | Cytochrome b-245, beta polypeptide [Homo sapiens] | Cytochrome b558 subunit beta | Heme-binding membrane glycoprotein gp91phox | NADPH oxidase 2 | NADPH oxidase 2 (NOX2) | NOX2 | Neutrophil cytochrome b 91 kDa polypeptide | Superoxide-generating NADPH oxidase heavy chain subunit | gp91-1 | gp91-phox | p22 phagocyte B-cytochrome
Type:
Enzyme
Mol. Mass.:
65355.82
Organism:
Homo sapiens (Human)
Description:
P04839
Residue:
570
Sequence:
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF
  
Inhibitor
Name:
BDBM318936
Synonyms:
US10173988, Compound A
Type:
Small organic molecule
Emp. Form.:
C23H29N7O
Mol. Mass.:
419.5227
SMILES:
COc1cccc(c1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1
Structure:
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