Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50190057
Substrate
n/a
Meas. Tech.
ChEMBL_393313 (CHEMBL911523)
Ki
47±n/a nM
Citation
 Su, J; Tang, H; McKittrick, BA; Burnett, DA; Zhang, H; Smith-Torhan, A; Fawzi, A; Lachowicz, J Modification of the clozapine structure by parallel synthesis. Bioorg Med Chem Lett 16:4548-53 (2006) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50190057
Synonyms:
CHEMBL215885 | N-[8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e][1,4]diazepin-5-yl]-4-methoxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C26H26ClN5O2
Mol. Mass.:
475.97
SMILES:
COc1ccc(cc1)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc12 |t:21|
Structure:
Search PDB for entries with ligand similarity: