Reaction Details Report a problem with these data
Target
Glutathione hydrolase 1 proenzyme
Ligand
BDBM50104413
Substrate
n/a
Meas. Tech.
ChEMBL_2262434 (CHEMBL5217445)
Ki
25±n/a nM
Citation
 Nguyen, L; Schultz, DC; Terzyan, SS; Rezaei, M; Songb, J; Li, C; You, Y; Hanigan, MH Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg Med Chem 73:0 (2022) [PubMed] 
Target
Name:
Glutathione hydrolase 1 proenzyme
Synonyms:
GGT | GGT1 | GGT1_HUMAN | Gamma-glutamyltranspeptidase 1
Type:
PROTEIN
Mol. Mass.:
61413.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543160
Residue:
569
Sequence:
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
  
Inhibitor
Name:
BDBM50104413
Synonyms:
CHEMBL87796 | Glutamyl-gamma-boronate analogue
Type:
Small organic molecule
Emp. Form.:
C4H10BNO4
Mol. Mass.:
146.938
SMILES:
N[C@@H](CCB(O)O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: