Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 6 group A member 1
Ligand
BDBM50607280
Substrate
n/a
Meas. Tech.
ChEMBL_2262522 (CHEMBL5217533)
EC50
<7000±n/a nM
Citation
 Yu, W; Xie, X; Ma, Y; Fang, S; Dong, Y; Liu, G Identification of 1,4-Benzodiazepine-2,5-dione Derivatives as Potential Protein Synthesis Inhibitors with Highly Potent Anticancer Activity. J Med Chem 65:14891-14915 (2022) [PubMed] 
Target
Name:
Nuclear receptor subfamily 6 group A member 1
Synonyms:
GCNF | NR6A1 | NR6A1_HUMAN
Type:
PROTEIN
Mol. Mass.:
54379.86
Organism:
Homo sapiens
Description:
ChEMBL_104478
Residue:
480
Sequence:
MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTISVSDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE
  
Inhibitor
Name:
BDBM50607280
Synonyms:
CHEMBL5219092
Type:
Small organic molecule
Emp. Form.:
C29H22BrClN2O2S
Mol. Mass.:
577.919
SMILES:
Clc1ccc(Sc2ccccc2CN2[C@H](Cc3ccccc3)C(=O)Nc3ccc(Br)cc3C2=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: