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Target
Complement factor D
Ligand
BDBM474862
Substrate
n/a
Meas. Tech.
ChEMBL_2262720 (CHEMBL5217731)
Ki
19±n/a nM
Citation
 Zhang, W; Wu, M; Vadlakonda, S; Juarez, L; Cheng, X; Muppa, S; Chintareddy, V; Vogeti, L; Kellogg-Yelder, D; Williams, J; Polach, K; Chen, X; Raman, K; Babu, YS; Kotian, P Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg Med Chem 74:0 (2022) [PubMed] 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM474862
Synonyms:
US10849883, Compound 279a | US11559515, Compound 279a
Type:
Small organic molecule
Emp. Form.:
C30H36ClFN8O4
Mol. Mass.:
627.109
SMILES:
CN(C1CCN(C)CC1)C(=O)Nc1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C3CC3)nc(C(N)=O)c2c1
Structure:
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