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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50607643
Substrate
n/a
Meas. Tech.
ChEMBL_2263018 (CHEMBL5218029)
IC50
1.7±n/a nM
Citation
 Hu, B; Toda, K; Wang, X; Antczak, MI; Smith, J; Geboers, S; Nishikawa, G; Li, H; Dawson, D; Fink, S; Desai, AB; Williams, NS; Markowitz, SD; Ready, JM Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration. J Med Chem 65:15327-15343 (2022) [PubMed] 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50607643
Synonyms:
CHEMBL5220207 | US11718589, Compound 49b
Type:
Small organic molecule
Emp. Form.:
C23H20N4O
Mol. Mass.:
368.4311
SMILES:
O=C(N1CCCCC1)c1ccc2ncc(nc2c1)-c1ccc2cnccc2c1
Structure:
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