Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50191801
Substrate
n/a
Meas. Tech.
ChEMBL_397231 (CHEMBL864277)
IC50
9±n/a nM
Citation
 Butora, G; Morriello, GJ; Kothandaraman, S; Guiadeen, D; Pasternak, A; Parsons, WH; MacCoss, M; Vicario, PP; Cascieri, MA; Yang, L 4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties. Bioorg Med Chem Lett 16:4715-22 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50191801
Synonyms:
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(cyclopropylmethyl)-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide | CHEMBL215020
Type:
Small organic molecule
Emp. Form.:
C31H34F6N2O
Mol. Mass.:
564.6049
SMILES:
C[C@H]1CN(CC[C@H](CC2CC2)C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)CC[C@@]11C=Cc2ccccc12 |c:35|
Structure:
Search PDB for entries with ligand similarity: