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Target
Somatostatin receptor type 2
Ligand
BDBM405596
Substrate
n/a
Meas. Tech.
ChEMBL_2265916
EC50
0.340000±n/a nM
Citation
 Zhao, J; Wang, S; Markison, S; Kim, SH; Han, S; Chen, M; Kusnetzow, AK; Rico-Bautista, E; Johns, M; Luo, R; Struthers, RS; Madan, A; Zhu, Y; Betz, SF Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist. ACS Med Chem Lett 14:66-74 (2023) [PubMed] 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM405596
Synonyms:
US10351547, Compound 2-10 | US10597377, Compound 2-10
Type:
Small organic molecule
Emp. Form.:
C27H21F3N4O
Mol. Mass.:
474.477
SMILES:
NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cc(F)cc(C#N)c1O)-c1cc(F)cc(F)c1
Structure:
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