Reaction Details Report a problem with these data
Target
Caspase-6
Ligand
BDBM50192784
Substrate
n/a
Meas. Tech.
ChEMBL_393612 (CHEMBL913238)
IC50
3700±n/a nM
Citation
 Zhou, D; Chu, W; Rothfuss, J; Zeng, C; Xu, J; Jones, L; Welch, MJ; Mach, RH Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorg Med Chem Lett 16:5041-6 (2006) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM50192784
Synonyms:
(S)-1-(4-(2-fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione | (S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin | 1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione | CHEMBL213759
Type:
Small organic molecule
Emp. Form.:
C28H27FN2O6S
Mol. Mass.:
538.587
SMILES:
FCCOc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccccc2)cc1
Structure:
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