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Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM7459
Substrate
n/a
Meas. Tech.
ChEMBL_2268093
IC50
1900±n/a nM
Citation
 Fiorentino, F; Mai, A; Rotili, D Emerging Therapeutic Potential of SIRT6 Modulators. J Med Chem 64:9732-9758 (2021) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM7459
Synonyms:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one | CHEMBL151 | Luteolin (27) | Luteolin (4) | acs.jmedchem.1c00409_ST.600 | cid_5280445 | luteolin | med.21724, Compound 3
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Structure:
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