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Target
Sentrin-specific protease 2
Ligand
BDBM50591766
Substrate
n/a
Meas. Tech.
ChEMBL_2269408
IC50
3700±n/a nM
Citation
 Wei, J; Wang, H; Zheng, Q; Zhang, J; Chen, Z; Wang, J; Ouyang, L; Wang, Y Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers. Eur J Med Chem 241:0 (2022) [PubMed] 
Target
Name:
Sentrin-specific protease 2
Synonyms:
KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2)
Type:
Protein
Mol. Mass.:
67890.62
Organism:
Homo sapiens (Human)
Description:
Q9HC62
Residue:
589
Sequence:
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
  
Inhibitor
Name:
BDBM50591766
Synonyms:
CHEMBL5188918
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N4O5
Mol. Mass.:
465.287
SMILES:
Cc1cc(OCC(=O)Nc2nonc2NC(=O)COc2ccc(Cl)c(C)c2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: