Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50194456
Substrate
n/a
Meas. Tech.
ChEMBL_424391 (CHEMBL911322)
Ki
11±n/a nM
Citation
 Kolanos, R; Dukat, M; Roth, BL; Glennon, RA Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg Med Chem Lett 16:5832-5 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50194456
Synonyms:
2-(4-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl)-N,N-dimethylethanamine | CHEMBL220566
Type:
Small organic molecule
Emp. Form.:
C19H22N2O3S
Mol. Mass.:
358.455
SMILES:
COc1cccc2n(cc(CCN(C)C)c12)S(=O)(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: