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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50194868
Substrate
n/a
Meas. Tech.
ChEMBL_424575 (CHEMBL853926)
IC50
30±n/a nM
Citation
 Liu, G; Zhao, H; Liu, B; Xin, Z; Liu, M; Kosogof, C; Szczepankiewicz, BG; Wang, S; Clampit, JE; Gum, RJ; Haasch, DL; Trevillyan, JM; Sham, HL Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond. Bioorg Med Chem Lett 16:5723-30 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50194868
Synonyms:
(S)-N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(1-hydroxypropan-2-ylamino)picolinamide | CHEMBL221227
Type:
Small organic molecule
Emp. Form.:
C18H21N5O4S
Mol. Mass.:
403.455
SMILES:
C[C@@H](CO)Nc1nc(cc(N)c1C#N)C(=O)NCc1ccc(cc1)S(C)(=O)=O |r|
Structure:
Search PDB for entries with ligand similarity: