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Target
D(4) dopamine receptor
Ligand
BDBM50059492
Substrate
n/a
Meas. Tech.
ChEMBL_2272041
Ki
7.5±n/a nM
Citation
 Salehian, F; Nadri, H; Jalili-Baleh, L; Youseftabar-Miri, L; Abbas Bukhari, SN; Foroumadi, A; Tüylü Küçükkilinç, T; Sharifzadeh, M; Khoobi, M A review: Biologically active 3,4-heterocycle-fused coumarins. Eur J Med Chem 212:0 (2021) [PubMed] 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50059492
Synonyms:
3-(4-Fluoro-benzyl)-8-methyl-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one | CHEMBL314285
Type:
Small organic molecule
Emp. Form.:
C20H18FNO2
Mol. Mass.:
323.3608
SMILES:
Cc1ccc2c3CCN(Cc4ccc(F)cc4)Cc3c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: