Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1
Ligand
BDBM50195448
Substrate
n/a
Meas. Tech.
ChEMBL_424982 (CHEMBL910739)
Kd
45000±n/a nM
Citation
 Chen, F; Hancock, CN; Macias, AT; Joh, J; Still, K; Zhong, S; MacKerell, AD; Shapiro, P Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. Bioorg Med Chem Lett 16:6281-7 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50195448
Synonyms:
1-(4-bromophenyl)-2-(5-(furan-2-yl)-4H-1,2,4-triazol-3-ylthio)ethanone | CHEMBL222841
Type:
Small organic molecule
Emp. Form.:
C14H10BrN3O2S
Mol. Mass.:
364.217
SMILES:
Brc1ccc(cc1)C(=O)CSc1nnc([nH]1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: