Reaction Details Report a problem with these data
Target
Sodium/nucleoside cotransporter 1
Ligand
BDBM50608215
Substrate
n/a
Meas. Tech.
ChEMBL_2273268
IC50
49000±n/a nM
Citation
 Jacobson, KA; Salmaso, V; Suresh, RR; Tosh, DK Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets. RSC Med Chem 12:1808-1825 (2021) [PubMed] 
Target
Name:
Sodium/nucleoside cotransporter 1
Synonyms:
CNT1 | S28A1_HUMAN | SLC28A1
Type:
PROTEIN
Mol. Mass.:
71589.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1494515
Residue:
649
Sequence:
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
  
Inhibitor
Name:
BDBM50608215
Synonyms:
CHEMBL5270911
Type:
Small organic molecule
Emp. Form.:
C12H15N5O2
Mol. Mass.:
261.2798
SMILES:
[H][C@]12C[C@]1(CO)[C@@H](O)C[C@@H]2n1cnc2c(N)ncnc12 |r|
Structure:
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