Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50609113
Substrate
n/a
Meas. Tech.
ChEMBL_2276501
Ki
2.0±n/a nM
Citation
 Mancini, RS; Barden, CJ; Weaver, DF; Reed, MA Furazans in Medicinal Chemistry. J Med Chem 64:1786-1815 (2021) [PubMed] 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50609113
Synonyms:
CHEMBL5276441
Type:
Small organic molecule
Emp. Form.:
C21H29N5O2S
Mol. Mass.:
415.552
SMILES:
CN(C)Cc1ccc(CSCCNc2nonc2NCCCc2ccccc2)o1
Structure:
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