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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50609430
Substrate
n/a
Meas. Tech.
ChEMBL_2277852
EC50
0.270000±n/a nM
Citation
 Sun, D; Zhang, J; Dong, G; He, S; Sheng, C Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation. J Med Chem 65:14276-14288 (2022) [PubMed] 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50609430
Synonyms:
CHEMBL5275279
Type:
Small organic molecule
Emp. Form.:
C75H107N7O20
Mol. Mass.:
1426.687
SMILES:
[H][C@@]1(C[C@@H](C)[C@@H]2CC(=O)C(C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CCC(OCCOCc2cn(CCOCCOCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)nn2)C(C1)OC |r,c:11,30,t:26,28|
Structure:
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