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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50197452
Substrate
n/a
Meas. Tech.
ChEMBL_432256 (CHEMBL914034)
IC50
1.2±n/a nM
Citation
 Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem 15:1067-82 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3
Type:
PROTEIN
Mol. Mass.:
68455.12
Organism:
Macaca fascicularis
Description:
ChEMBL_61362
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50197452
Synonyms:
(1R)-methyl 3-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylate | CHEMBL388633
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2NO2
Mol. Mass.:
326.218
SMILES:
COC(=O)C1=C(CC2CC[C@H]1N2C)c1ccc(Cl)c(Cl)c1 |t:4,TLB:13:5:11:9.8,THB:2:4:11:9.8|
Structure:
Search PDB for entries with ligand similarity: