Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 8
Ligand
BDBM50610461
Substrate
n/a
Meas. Tech.
ChEMBL_2280981
Kd
30±n/a nM
Citation
 Wu, D; Zhang, Z; Chen, X; Yan, Y; Liu, X Angel or Devil ? - CDK8 as the new drug target. Eur J Med Chem 213:0 (2021) [PubMed] 
Target
Name:
Cyclin-dependent kinase 8
Synonyms:
CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Type:
Serine/threonine-protein kinase
Mol. Mass.:
53300.21
Organism:
Homo sapiens (Human)
Description:
P49336
Residue:
464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
  
Inhibitor
Name:
BDBM50610461
Synonyms:
CHEMBL5270079
Type:
Small organic molecule
Emp. Form.:
C37H51N9O2
Mol. Mass.:
653.8599
SMILES:
Cc1ccc(cc1)-n1nc(cc1NC(=O)NCCCN1CCN(CC1)C(=O)Nc1cc(nn1-c1ccc(C)cc1)C(C)(C)C)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: