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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50611744
Substrate
n/a
Meas. Tech.
ChEMBL_2284022
IC50
0.500000±n/a nM
Citation
 Gür, ZT; Çal??kan, B; Banoglu, E Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. Eur J Med Chem 153:34-48 (2018) [PubMed] 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50611744
Synonyms:
CHEMBL5283430
Type:
Small organic molecule
Emp. Form.:
C27H30N6O
Mol. Mass.:
454.5667
SMILES:
CC(C)C(C)(c1ccc(cc1)-c1cnc(N)nc1)c1ccc(cn1)-c1ccc(nn1)C(C)(C)O
Structure:
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