Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 3
Ligand
BDBM50514451
Substrate
n/a
Meas. Tech.
ChEMBL_2285458
IC50
3500±n/a nM
Citation
 Tao, Y; Hao, X; Ding, X; Cherukupalli, S; Song, Y; Liu, X; Zhan, P Medicinal chemistry insights into novel CDC25 inhibitors. Eur J Med Chem 201:0 (2020) [PubMed] 
Target
Name:
M-phase inducer phosphatase 3
Synonyms:
CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN
Type:
Substrate
Mol. Mass.:
53366.11
Organism:
Homo sapiens (Human)
Description:
P30307
Residue:
473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
  
Inhibitor
Name:
BDBM50514451
Synonyms:
CHEMBL1967787
Type:
Small organic molecule
Emp. Form.:
C20H18O5
Mol. Mass.:
338.3539
SMILES:
OC(=O)C1CCCCC1c1c2ccc(O)cc2oc2cc(=O)ccc12
Structure:
Search PDB for entries with ligand similarity: