Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase ULK2
Ligand
BDBM50612791
Substrate
n/a
Meas. Tech.
ChEMBL_2289888
IC50
2.6±n/a nM
Citation
 Ye, W; Fan, C; Fu, K; Wang, X; Lin, J; Nian, S; Liu, C; Zhou, W The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance. Eur J Med Chem 244:0 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase ULK2
Synonyms:
KIAA0623 | ULK2 | ULK2_HUMAN | Unc-51-like kinase 2
Type:
PROTEIN
Mol. Mass.:
112726.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510276
Residue:
1036
Sequence:
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
  
Inhibitor
Name:
BDBM50612791
Synonyms:
CHEMBL5280560
Type:
Small organic molecule
Emp. Form.:
C29H34F3N5O2S
Mol. Mass.:
573.673
SMILES:
CC(C)[C@H](NC(=O)c1cc(cs1)C1NN2C=CC(=NC2=C1)c1ccc(OCCN2CCCCC2)cc1)C(F)(F)F |r,c:16,18,21|
Structure:
Search PDB for entries with ligand similarity: