Reaction Details Report a problem with these data
Target
Taste receptor type 2 member 14
Ligand
BDBM50613038
Substrate
n/a
Meas. Tech.
ChEMBL_2290791
EC50
300±n/a nM
Citation
 Waterloo, L; Hübner, H; Fierro, F; Pfeiffer, T; Brox, R; Löber, S; Weikert, D; Niv, MY; Gmeiner, P Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14. J Med Chem 66:3499-3521 (2023) [PubMed] 
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
  
Inhibitor
Name:
BDBM50613038
Synonyms:
CHEMBL5277281
Type:
Small organic molecule
Emp. Form.:
C13H7F3N8
Mol. Mass.:
332.2435
SMILES:
FC(F)(F)c1cc(nc(Nc2ccccc2-c2nnn[nH]2)n1)C#N
Structure:
Search PDB for entries with ligand similarity: