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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50613703
Substrate
n/a
Meas. Tech.
ChEMBL_2293100
IC50
18700±n/a nM
Citation
 Soukarieh, F; Nowicki, MW; Bastide, A; Pöyry, T; Jones, C; Dudek, K; Patwardhan, G; Meullenet, F; Oldham, NJ; Walkinshaw, MD; Willis, AE; Fischer, PM Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur J Med Chem 124:200-217 (2016) [PubMed] 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50613703
Synonyms:
CHEMBL5286550
Type:
Small organic molecule
Emp. Form.:
C18H21N6O8S
Mol. Mass.:
481.459
SMILES:
C[n+]1cn([C@@H]2O[C@H](CNS(=O)(=O)c3ccc(cc3)C(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Structure:
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