Reaction Details Report a problem with these data
Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50614281
Substrate
n/a
Meas. Tech.
ChEMBL_2296198
IC50
15±n/a nM
Citation
 Gannett, C; Banks, P; Chuong, C; Weger-Lucarelli, J; Mevers, E; Lowell, AN Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity. RSC Med Chem 14:782-789 (2023) [PubMed] 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
  
Inhibitor
Name:
BDBM50614281
Synonyms:
CHEMBL5288022
Type:
Small organic molecule
Emp. Form.:
C24H32N8O5
Mol. Mass.:
512.5615
SMILES:
CN(CC[C@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)OCc1ccccc1)n1ccc(N)nc1=O)C(N)=N |r,c:11|
Structure:
Search PDB for entries with ligand similarity: