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Target
Serine/threonine-protein kinase Sgk3
Ligand
BDBM50242733
Substrate
n/a
Meas. Tech.
ChEMBL_2296410
IC50
50±n/a nM
Citation
 Feng, Y; LoGrasso, PV; Defert, O; Li, R Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. J Med Chem 59:2269-300 (2016) [PubMed] 
Target
Name:
Serine/threonine-protein kinase Sgk3
Synonyms:
CISK | Cytokine-independent survival kinase | SGK3 | SGK3_HUMAN | SGKL | Serum/glucocorticoid-regulated kinase 3 | Serum/glucocorticoid-regulated kinase-like
Type:
PROTEIN
Mol. Mass.:
57110.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445194
Residue:
496
Sequence:
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
  
Inhibitor
Name:
BDBM50242733
Synonyms:
AT-13148
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O
Mol. Mass.:
313.781
SMILES:
NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1
Structure:
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