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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50615227
Substrate
n/a
Meas. Tech.
ChEMBL_2300376
Kd
720±n/a nM
Citation
 Johannes, JW; Bates, S; Beigie, C; Belmonte, MA; Breen, J; Cao, S; Centrella, PA; Clark, MA; Cuozzo, JW; Dumelin, CE; Ferguson, AD; Habeshian, S; Hargreaves, D; Joubran, C; Kazmirski, S; Keefe, AD; Lamb, ML; Lan, H; Li, Y; Ma, H; Mlynarski, S; Packer, MJ; Rawlins, PB; Robbins, DW; Shen, H; Sigel, EA; Soutter, HH; Su, N; Troast, DM; Wang, H; Wickson, KF; Wu, C; Zhang, Y; Zhao, Q; Zheng, X; Hird, AW Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors. ACS Med Chem Lett 8:239-244 (2017) [PubMed] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50615227
Synonyms:
CHEMBL5288551
Type:
Small organic molecule
Emp. Form.:
C36H42Cl2N6O6S
Mol. Mass.:
757.726
SMILES:
CN1CCCN[C@@H](Cc2ccc(cc2)S(N)(=O)=O)CC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N[C@H](Cc3ccc(Cl)c(Cl)c3)CC1=O)C2=O |r|
Structure:
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