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Target
Polymerase basic protein 2
Ligand
BDBM50615247
Substrate
n/a
Meas. Tech.
ChEMBL_2300431
Kd
3.0±n/a nM
Citation
 Farmer, LJ; Clark, MP; Boyd, MJ; Perola, E; Jones, SM; Tsai, A; Jacobs, MD; Bandarage, UK; Ledeboer, MW; Wang, T; Deng, H; Ledford, B; Gu, W; Duffy, JP; Bethiel, RS; Shannon, D; Byrn, RA; Leeman, JR; Rijnbrand, R; Bennett, HB; O'Brien, C; Memmott, C; Nti-Addae, K; Bennani, YL; Charifson, PS Discovery of Novel, Orally Bioavailable ?-Amino Acid Azaindole Inhibitors of Influenza PB2. ACS Med Chem Lett 8:256-260 (2017) [PubMed] 
Target
Name:
Polymerase basic protein 2
Synonyms:
PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3
Type:
PROTEIN
Mol. Mass.:
86120.80
Organism:
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Description:
ChEMBL_109460
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPITNTVHYPKIYKTYFERVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGVEPIDNVMGMIGILPDMTPSIEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSRMQFSSFTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM50615247
Synonyms:
CHEMBL5283800
Type:
Small organic molecule
Emp. Form.:
C18H19F2N5O2
Mol. Mass.:
375.3726
SMILES:
CC(C)(C)[C@@H](CC(O)=O)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r|
Structure:
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