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Target
Cathepsin B
Ligand
BDBM50201701
Substrate
n/a
Meas. Tech.
ChEMBL_438177 (CHEMBL907570)
IC50
1±n/a nM
Citation
 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett 17:1254-9 (2007) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50201701
Synonyms:
CHEMBL390474 | cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3.2.1]octan-7-one
Type:
Small organic molecule
Emp. Form.:
C14H17NO3
Mol. Mass.:
247.2897
SMILES:
Cc1cccc(O[C@H]2CCN3C[C@H]2OC3=O)c1C
Structure:
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