Reaction Details Report a problem with these data
Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM50615683
Substrate
n/a
Meas. Tech.
ChEMBL_2303790
IC50
78±n/a nM
Citation
 Han, X; Wang, C; Qin, C; Xiang, W; Fernandez-Salas, E; Yang, CY; Wang, M; Zhao, L; Xu, T; Chinnaswamy, K; Delproposto, J; Stuckey, J; Wang, S Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem 62:941-964 (2019) [PubMed] 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM50615683
Synonyms:
CHEMBL5274336
Type:
Small organic molecule
Emp. Form.:
C29H38FN5O5S
Mol. Mass.:
587.706
SMILES:
CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)C1(F)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
Structure:
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