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Target
Dual specificity protein phosphatase 22
Ligand
BDBM50205419
Substrate
n/a
Meas. Tech.
ChEMBL_438363 (CHEMBL887465)
IC50
2350±n/a nM
Citation
 Zhang, L; Qiu, B; Xiong, B; Li, X; Li, J; Wang, X; Li, J; Shen, J Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors. Bioorg Med Chem Lett 17:2118-22 (2007) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 22
Synonyms:
DUS22_HUMAN | DUSP22 | Dual specificity phosphatase 22 | Dual specificity protein phosphatase (MKPX) | Dual specificity protein phosphatase 22 | Dual specificity protein phosphatase 22 (VHX) | Dual specificity protein phosphatase VHX (VHX) | JSP1 | LMWDSP2 | MKPX | Mitogen-activated protein kinase phosphatase x | VHX
Type:
Protein
Mol. Mass.:
20915.83
Organism:
Homo sapiens (Human)
Description:
Q9NRW4
Residue:
184
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
  
Inhibitor
Name:
BDBM50205419
Synonyms:
CHEMBL230472 | N3-butyl-N1-(2,3-di(furan-2-yl)quinoxalin-6-yl)-N3-ethylpiperidine-1,3-dicarboxamide
Type:
Small organic molecule
Emp. Form.:
C29H33N5O4
Mol. Mass.:
515.6034
SMILES:
CCCCN(CC)C(=O)C1CCCN(C1)C(=O)Nc1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1 |w:9.8|
Structure:
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