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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50207580
Substrate
n/a
Meas. Tech.
ChEMBL_443066 (CHEMBL892197)
IC50
1.42±n/a nM
Citation
 Zhang, R; Lei, L; Xu, YG; Hua, WY; Gong, GQ Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury. Bioorg Med Chem Lett 17:2430-3 (2007) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50207580
Synonyms:
CHEMBL234074 | N-[3-(5-nitro-1H-benzoimidazol-2-yl)-benzoyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C15H12N6O3
Mol. Mass.:
324.2942
SMILES:
NC(=N)NC(=O)c1cccc(c1)-c1nc2ccc(cc2[nH]1)[N+]([O-])=O
Structure:
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