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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50207775
Substrate
n/a
Meas. Tech.
ChEMBL_454895 (CHEMBL886924)
IC50
53000±n/a nM
Citation
Webster, SP; Ward, P; Binnie, M; Craigie, E; McConnell, KM; Sooy, K; Vinter, A; Seckl, JR; Walker, BR Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 17:2838-43 (2007) [PubMed] Article
More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Human
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50207775
Synonyms:
(4-ethyl-piperazin-1-yl)-(3-hydroxy-adamantan-1-yl)-methanone | CHEMBL395391
Type:
Small organic molecule
Emp. Form.:
C17H28N2O2
Mol. Mass.:
292.4164
SMILES:
CCN1CCN(CC1)C(=O)C12CC3CC(CC(O)(C3)C1)C2 |w:14.15,12.12,TLB:18:12:20:19.16.15,18:16:11.12.13:20,THB:17:16:11:13.14.20,17:16:11.12.13:20,15:16:11:13.14.20,TEB:15:14:11:19.18.16|