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Target
Estrogen receptor beta
Ligand
BDBM50212157
Substrate
n/a
Meas. Tech.
ChEMBL_438781 (CHEMBL889119)
Ki
0.29±n/a nM
Citation
 Richardson, TI; Frank, SA; Wang, M; Clarke, CA; Jones, SA; Ying, BP; Kohlman, DT; Wallace, OB; Shepherd, TA; Dally, RD; Palkowitz, AD; Geiser, AG; Bryant, HU; Henck, JW; Cohen, IR; Rudmann, DG; McCann, DJ; Coutant, DE; Oldham, SW; Hummel, CW; Fong, KC; Hinklin, R; Lewis, G; Tian, H; Dodge, JA Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety. Bioorg Med Chem Lett 17:3544-9 (2007) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50212157
Synonyms:
6-(3,4-difluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | CHEMBL244206
Type:
Small organic molecule
Emp. Form.:
C29H27F2NO3
Mol. Mass.:
475.5264
SMILES:
Oc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(ccc2c1)-c1ccc(F)c(F)c1
Structure:
Search PDB for entries with ligand similarity: