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Target
Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Ligand
BDBM50212170
Substrate
n/a
Meas. Tech.
ChEMBL_455656 (CHEMBL886439)
IC50
624±n/a nM
Citation
 Vu, AT; Campbell, AN; Harris, HA; Unwalla, RJ; Manas, ES; Mewshaw, RE ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett 17:4053-6 (2007) [PubMed]  Article 
Target
Name:
Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | Estrogen-related receptor, beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Type:
PROTEIN
Mol. Mass.:
56220.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_940755
Residue:
508
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSPTPLNERGRQISPSTRTPGGQGKHLWLTM
  
Inhibitor
Name:
BDBM50212170
Synonyms:
7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol | CHEMBL250301
Type:
Small organic molecule
Emp. Form.:
C18H11NO3
Mol. Mass.:
289.2848
SMILES:
Oc1ccc-2c(OCc3c-2nc2ccc(O)cc2c3C#C)c1
Structure:
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