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Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50212235
Substrate
n/a
Meas. Tech.
ChEMBL_459062 (CHEMBL925154)
IC50
8±n/a nM
Citation
 Patel, MR; Talele, TT 3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors. Bioorg Med Chem 15:4470-81 (2007) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50212235
Synonyms:
CHEMBL400455 | N-(4-(1H-tetrazol-5-yl)butyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)isobutyramide | N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Type:
Small organic molecule
Emp. Form.:
C18H21F6N5O2
Mol. Mass.:
453.3821
SMILES:
CC(C)C(=O)N(CCCCc1nnn[nH]1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Structure:
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