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Target
Melanocortin receptor 4
Ligand
BDBM50214704
Substrate
n/a
Meas. Tech.
ChEMBL_448087 (CHEMBL898343)
Ki
1±n/a nM
Citation
 Tran, JA; Tucci, FC; Jiang, W; Marinkovic, D; Chen, CW; Arellano, M; Markison, S; Fleck, BA; Wen, J; White, NS; Pontillo, J; Saunders, J; Marks, D; Hoare, SR; Madan, A; Foster, AC; Chen, C Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. Bioorg Med Chem 15:5166-76 (2007) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50214704
Synonyms:
1-{4-[(1S)-2-(amino-3-methylbutyl)-4-fluorophenyl]-4-[(2R)-(3-aminopropionylamido)-3-(2,4-dichlorophenyl)-propionyl]}-piperazine | CHEMBL393716
Type:
Small organic molecule
Emp. Form.:
C28H36Cl2F3N5O2
Mol. Mass.:
602.519
SMILES:
CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)NC(=O)CCN)C(F)(F)F
Structure:
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