Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50214966
Substrate
n/a
Meas. Tech.
ChEMBL_447651 (CHEMBL896658)
EC50
240±n/a nM
Citation
 Havranek, M; Sauerberg, P; Mogensen, JP; Kratina, P; Jeppesen, CB; Pettersson, I; Pihera, P Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. Bioorg Med Chem Lett 17:4144-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50214966
Synonyms:
(Z)-2-(4-(4-(4-bromophenyl)-6-(pyridin-2-yl)hex-2-en-5-ynyloxy)-2-methylphenoxy)acetic acid | CHEMBL234689
Type:
Small organic molecule
Emp. Form.:
C26H22BrNO4
Mol. Mass.:
492.361
SMILES:
Cc1cc(OC\C=C/C(C#Cc2ccccn2)c2ccc(Br)cc2)ccc1OCC(O)=O |w:8.7|
Structure:
Search PDB for entries with ligand similarity: