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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50216909
Substrate
n/a
Meas. Tech.
ChEMBL_448530 (CHEMBL897679)
Ki
25±n/a nM
Citation
 Sutin, L; Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; James, S; Henriksson, M; Johansson, L; Kaiser, C; Flyrén, K; Williams, M Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 17:4837-40 (2007) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50216909
Synonyms:
2-(3-hydroxy-adamantan-1-ylamino)-5-isopropyl-5-methyl-oxazol-4-one | CHEMBL235018
Type:
Small organic molecule
Emp. Form.:
C17H26N2O3
Mol. Mass.:
306.3999
SMILES:
CC(C)C1(C)OC(NC23CC4CC(CC(O)(C4)C2)C3)=NC1=O |c:21,TLB:15:14:11.12.18:9,7:8:11:16.13.14,THB:15:14:11:18.8.9,17:14:11:18.8.9,17:8:11:16.13.14,13:12:9:16.14.17,13:14:11.12.18:9|
Structure:
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