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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50216911
Substrate
n/a
Meas. Tech.
ChEMBL_448530 (CHEMBL897679)
Ki
18±n/a nM
Citation
 Sutin, L; Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; James, S; Henriksson, M; Johansson, L; Kaiser, C; Flyrén, K; Williams, M Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 17:4837-40 (2007) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50216911
Synonyms:
2-(adamantan-2-ylamino)-1-oxa-3-aza-spiro[4.4]non-2-en-4-one | CHEMBL396387
Type:
Small organic molecule
Emp. Form.:
C17H24N2O2
Mol. Mass.:
288.3847
SMILES:
O=C1N=C(NC2C3CC4CC(C3)CC2C4)OC11CCCC1 |t:2,TLB:11:10:14:7.6.5,11:6:9.10.12:14,THB:5:6:9:12.13.14,5:13:9:7.11.6,4:5:9.10.12:14,(15.11,-27.99,;13.58,-28.24,;12.49,-27.15,;11.15,-27.92,;9.82,-27.16,;8.55,-28.03,;8.54,-29.56,;7.14,-29.9,;5.81,-29.42,;4.62,-30.69,;6.12,-30.27,;7.52,-30.84,;6.11,-28.68,;7.16,-27.45,;5.81,-27.93,;11.37,-29.39,;12.89,-29.62,;12.11,-30.95,;13.13,-32.1,;14.54,-31.48,;14.39,-29.95,)|
Structure:
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