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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50218817
Substrate
n/a
Meas. Tech.
ChEMBL_440685 (CHEMBL889782)
IC50
38±n/a nM
Citation
 Murali Dhar, TG; Wrobleski, ST; Lin, S; Furch, JA; Nirschl, DS; Fan, Y; Todderud, G; Pitt, S; Doweyko, AM; Sack, JS; Mathur, A; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds. Bioorg Med Chem Lett 17:5019-24 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50218817
Synonyms:
(3-(2,4-difluorophenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)(6-methoxy-1-methyl-1H-indol-5-yl)methanone | CHEMBL244164
Type:
Small organic molecule
Emp. Form.:
C23H20F2N4O2
Mol. Mass.:
422.4273
SMILES:
COc1cc2n(C)ccc2cc1C(=O)N1CCn2c(C1)cnc2-c1ccc(F)cc1F
Structure:
Search PDB for entries with ligand similarity: