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Target
C-X-C chemokine receptor type 3
Ligand
BDBM50225718
Substrate
n/a
Meas. Tech.
ChEMBL_458685 (CHEMBL942022)
Ki
100±n/a nM
Citation
 Watson, RJ; Allen, DR; Birch, HL; Chapman, GA; Hannah, DR; Knight, RL; Meissner, JW; Owen, DA; Thomas, EJ Development of CXCR3 antagonists. Part 2: Identification of 2-amino(4-piperidinyl)azoles as potent CXCR3 antagonists. Bioorg Med Chem Lett 17:6806-10 (2007) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50225718
Synonyms:
1-(1-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)piperidin-4-yl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)imidazolidine-2,4-dione | CHEMBL249178
Type:
Small organic molecule
Emp. Form.:
C25H29F4N3O2
Mol. Mass.:
479.5103
SMILES:
CC1(C)[C@@H]2C[C@H]1C(CN1CCC(CC1)n1cc(O)n(-c3cc(F)cc(c3)C(F)(F)F)c1=O)=CC2 |c:35|
Structure:
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