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Target
Cytosol aminopeptidase
Ligand
BDBM50234656
Substrate
n/a
Meas. Tech.
ChEMBL_462623 (CHEMBL929612)
Ki
8800±n/a nM
Citation
 Mucha, A; Lämmerhofer, M; Lindner, W; Pawelczak, M; Kafarski, P Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase. Bioorg Med Chem Lett 18:1550-4 (2008) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_HUMAN | Aminopeptidase | LAP3 | LAPEP | Leucine aminopeptidase | PEPS
Type:
PROTEIN
Mol. Mass.:
56171.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507539
Residue:
519
Sequence:
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
  
Inhibitor
Name:
BDBM50234656
Synonyms:
(R)-3-[((R)-1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-2-benzyl-propionic acid | CHEMBL252204 | CHEMBL254285
Type:
Small organic molecule
Emp. Form.:
C19H24NO4P
Mol. Mass.:
361.3719
SMILES:
OC(=O)[C@@H](Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Structure:
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