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Target
DNA polymerase beta
Ligand
BDBM50241929
Substrate
n/a
Meas. Tech.
ChEMBL_550664 (CHEMBL1002759)
IC50
12000±n/a nM
Citation
 Massiot, G; Long, C; David, B; Serrano, MJ; Daubié, F; Alby, F; Ausseil, F; Knibiehler, M; Moretti, C; Hoffmann, JS; Cazaux, C; Lavaud, C Acylphloroglucinol derivatives from Mahurea palustris. J Nat Prod 68:979-84 (2005) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50241929
Synonyms:
CHEMBL520861 | Mahureone D
Type:
Small organic molecule
Emp. Form.:
C32H48O6
Mol. Mass.:
528.7199
SMILES:
[#6]-[#6]-[#6]-[#6](-[#6]-[#6](-[#8])=O)-[#6]1=[#6]2-[#8]-[#6](=O)-[#6](-[#6](=O)-[#6]-[#6](-[#6])-[#6])-[#6](=O)C2([#6]\[#6]=[#6](\[#6])-[#6])[#6]-[#6](-[#6]\[#6]=[#6](\[#6])-[#6])C1([#6])[#6] |c:8|
Structure:
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