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Target
Glutathione hydrolase 1 proenzyme
Ligand
BDBM50248736
Substrate
n/a
Meas. Tech.
ChEMBL_543160 (CHEMBL1014320)
IC50
20000±n/a nM
Citation
 Sadanandam, YS; Shetty, MM; Rao, AB; Rambabu, Y 10H-Phenothiazines: a new class of enzyme inhibitors for inflammatory diseases. Eur J Med Chem 44:197-202 (2008) [PubMed]  Article 
Target
Name:
Glutathione hydrolase 1 proenzyme
Synonyms:
GGT | GGT1 | GGT1_HUMAN | Gamma-glutamyltranspeptidase 1
Type:
PROTEIN
Mol. Mass.:
61413.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543160
Residue:
569
Sequence:
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
  
Inhibitor
Name:
BDBM50248736
Synonyms:
2-Phenyl-N,N',4-trimethyl-10H-phenothiazine-1,3-dicarboxamide | CHEMBL465230
Type:
Small organic molecule
Emp. Form.:
C23H21N3O2S
Mol. Mass.:
403.497
SMILES:
CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: