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Target
Stromelysin-2
Ligand
BDBM50260826
Substrate
n/a
Meas. Tech.
ChEMBL_552278 (CHEMBL995608)
Ki
335±n/a nM
Citation
 Subramaniam, R; Haldar, MK; Tobwala, S; Ganguly, B; Srivastava, DK; Mallik, S Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett 18:3333-7 (2008) [PubMed]  Article 
Target
Name:
Stromelysin-2
Synonyms:
MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2
Type:
Enzyme
Mol. Mass.:
54143.02
Organism:
Homo sapiens (Human)
Description:
P09238
Residue:
476
Sequence:
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
  
Inhibitor
Name:
BDBM50260826
Synonyms:
CHEMBL497761 | N-hydroxy-2,3-bis(4-methoxyphenylsulfonamido)propanamide
Type:
Small organic molecule
Emp. Form.:
C17H21N3O8S2
Mol. Mass.:
459.494
SMILES:
COc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Structure:
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