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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270805
Substrate
n/a
Meas. Tech.
ChEMBL_552584 (CHEMBL956456)
IC50
>125000±n/a nM
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270805
Synonyms:
CHEMBL500525 | QRFCTGHFGALYPCNGP
Type:
Small organic molecule
Emp. Form.:
C83H118N24O22S2
Mol. Mass.:
1868.103
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O |r,wU:87.89,102.107,127.133,74.77,28.36,52.62,4.4,42.44,112.116,81.85,wD:8.8,63.73,17.25,46.50,106.110,(34.04,-31.2,;34.04,-32.73,;35.38,-33.51,;32.69,-33.51,;32.69,-35.03,;31.37,-35.81,;30.04,-35.04,;30.04,-33.51,;28.71,-35.8,;28.71,-37.34,;27.38,-35.03,;26.04,-35.79,;26.04,-37.34,;24.71,-35.02,;23.38,-35.79,;22.04,-35.03,;22.04,-33.5,;20.72,-35.79,;20.72,-37.34,;22.04,-38.1,;23.37,-37.35,;24.7,-38.12,;24.69,-39.67,;23.35,-40.43,;22.03,-39.65,;19.38,-35.03,;18.05,-35.8,;18.05,-37.35,;16.7,-35.03,;16.7,-33.5,;18.05,-32.73,;19.46,-33.38,;20.49,-32.24,;19.73,-30.9,;18.22,-31.2,;15.37,-35.8,;14.02,-35.04,;14.02,-33.51,;12.71,-35.8,;11.37,-35.03,;10.04,-35.8,;10.04,-37.36,;8.7,-35.03,;7.36,-35.79,;6.02,-35.04,;6.02,-33.52,;4.71,-35.8,;4.71,-37.35,;6.02,-38.11,;3.38,-35.01,;2.05,-35.79,;2.05,-37.35,;.71,-35.02,;.71,-33.5,;2.05,-32.72,;3.39,-33.51,;4.73,-32.75,;4.73,-31.21,;3.4,-30.44,;2.07,-31.2,;-.64,-35.77,;-1.99,-35.03,;-1.99,-33.5,;-3.32,-35.79,;-3.32,-37.34,;-2,-38.1,;-2,-39.65,;-.64,-40.38,;-.66,-41.92,;-2,-42.68,;.66,-42.67,;-4.62,-34.96,;-5.94,-35.76,;-5.94,-37.3,;-7.27,-34.98,;-8.57,-35.69,;-7.27,-33.45,;-5.93,-32.67,;-5.93,-31.14,;-7.23,-30.37,;-4.58,-30.37,;8.7,-33.5,;7.37,-32.74,;10.05,-32.73,;34.04,-35.81,;34.04,-37.36,;35.36,-35.04,;36.7,-35.82,;38.02,-35.06,;38.02,-33.54,;36.71,-32.76,;36.71,-31.22,;38.06,-30.46,;38.06,-28.93,;39.38,-31.23,;39.37,-32.78,;36.7,-37.37,;35.36,-38.15,;38.02,-38.13,;39.6,-37.59,;40.62,-38.92,;39.68,-40.31,;38.28,-39.62,;37.05,-40.55,;35.66,-39.88,;37.18,-42.08,;35.89,-42.94,;34.51,-42.26,;33.24,-43.12,;36.01,-44.47,;37.38,-45.14,;34.73,-45.34,;34.84,-46.87,;36.22,-47.55,;36.32,-49.09,;35.06,-49.95,;37.71,-49.75,;33.56,-47.74,;32.18,-47.06,;33.67,-49.27,;32.39,-50.13,;32.5,-51.66,;33.88,-52.33,;31.22,-52.52,;31.04,-54.19,;29.4,-54.53,;28.56,-53.08,;29.78,-52.11,;29.47,-50.61,;28.02,-50.12,;30.63,-49.59,)|
Structure:
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