Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50252113
Substrate
n/a
Meas. Tech.
ChEMBL_491756 (CHEMBL937827)
Ki
2.4±n/a nM
Citation
 Shah, U; Boyle, CD; Chackalamannil, S; Neustadt, BR; Lindo, N; Greenlee, WJ; Foster, C; Arik, L; Zhai, Y; Ng, K; Wang, S; Monopoli, A; Lachowicz, JE Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists. Bioorg Med Chem Lett 18:4199-203 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50252113
Synonyms:
2-Furan-2-yl-7-[2-(2-methyl-quinolin-6-yl)-ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine | CHEMBL520782
Type:
Small organic molecule
Emp. Form.:
C22H18N8O
Mol. Mass.:
410.4313
SMILES:
Cc1ccc2cc(CCn3ncc4c5nc(nn5c(N)nc34)-c3ccco3)ccc2n1
Structure:
Search PDB for entries with ligand similarity: